What are serotonin receptors?

The subdivision of serotonin (5-HT) receptors into three classes, designated 5-HT1, 5-HT2, and 5-HT3, are found in the central and peripheral nervous system. While the 5-HT 1B receptor is best known for its role in regulating aggressive and impulsive behaviour, it also plays an important role in modulating depression. Activation of the 5-HT 1B receptor decreases serotonin levels in the brain through effects on release, synthesis, and reuptake. Mechanism of the most effective antidepressant treatments – selective serotonin reuptake inhibitors. While the majority of the 15 known receptors for serotonin have been implicated in depression or depressive-like behaviour, the serotonin 1A (5-HT 1A) and 1B (5-HT 1B) receptors are among the most studied. Human brain imaging and genetic studies point to the involvement of 5-HT 1A and 5-HT 1B receptors in MDD and the response to antidepressant treatment.

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