Past studies

Randomised placebo controlled trial of Pramipexole addition to mood stabilisers for treatment resistant bipolar depression. PAX-BD was a major trial examining a novel treatment for bipolar disorder, funded by the NIHR HTA Board.

The Psilocybin Study was a multi-centred worldwide clinical trial examining the safety and efficacy of psilocybin (the ‘magic’ in ‘magic mushrooms’) in participants with treatment-resistant depression.

Lithium can effectively treat and prevent mania and depression, as well as reduce risk of suicide. However, it does not work for everyone. The BLISS is examining why lithium is an effective treatment for some patients with bipolar disorder but not others, using magnetic resonance techniques.

This study assessed sleep in patients with bipolar compared to healthy patients. It was found that patients with bipolar disorder had high rates of sleep problems, including insomnia, over-sleeping, obstructive sleep apnoea, and inconsistent patterns of going to sleep and waking up.

Electroconvulsive therapy (ECT) is an effective treatment for depression but has many side effects, particularly memory problems. This study explored whether ketamine may protect against memory problems from ECT. The results showed that ketamine made no difference to the beneficial effect of ECT.

Clinicians have worked collaboratively with young people and their families to develop an App for mood monitoring for young people aged 15-25 years with Early Onset Bipolar Disorder.

The CAPMEM study is exploring whether the autonomic nervous system works differently in people with mental health, neurodevelopmental, and neurodegenerative disorders and whether this explains the memory and concentration problems in these populations.

The ALFI study is examining the psychometric properties of a newly developed questionnaire (“ALFI”) in a sample of typically developing young people aged 16-25 years, to more accurately measure adaptive functioning in this population.

The EOD-UK & ROI study is investigating the incidence of first time diagnosis, management, clinical presentations, and outcome for children diagnosed with Early Onset Depression.

EPICC-ID is a trial evaluating the clinical and cost effectiveness of a parenting group, Level 4 Stepping Stones Triple P (SSTP), designed to reduce challenging behaviour in preschool children with a moderate to severe intellectual disability.