Current studies

Home-based transcranial direct current stimulation in bipolar disorder.

The EMBRACE trial is a clinical study investigating whether CYB003, an investigational psychedelic treatment combined with psychological support, is effective in treating major depressive disorder that has not responded adequately to antidepressants.

The Mental Health Mission Mood Disorder Cohort Study is a research study collecting clinical, questionnaire and biological data from people with difficult-to-treat depression or bipolar disorder to improve understanding of mood disorders and support the development of more effective treatments.

The Social Health Cohort Study is a research study investigating how social connectedness, relationships and community experiences affect mental health, wellbeing and recovery in people living with severe mental illness.

Imaging Lithium in Alzheimer’s Disease

RELMED is a research study focused on improving how we treat depression

This study is looking to understand if we can use small wearable sensors to measure the walking and movement of people with Bipolar Disorder.

Lithium Point-Of-Care testing to improve adherence to monitoring guidelines and quality of maintenance therapy: a randomised feasibility trial (LiPOC).

The effectiveness of Lithium plus Quetiapine COMBination versus LithIum versus QuetiapiNe monothErapy in the maintenance treatment of bipolaR disorder: the COMBINER trial.

A randomised, double-blind, placebo-controlled study followed by open-label treatment of ALTO-100 in adults with bipolar disorder currently experiencing a Major Depressive Episode

HOME is a study of transcranial direct current stimulation in major depression across 6 centres

Lithium's mechanism in bipolar disorder: Investigating the light hypersensitivity hypothesis

The SLIPI study will measure the effects of lithium orotate on peripheral biomarkers of inflammation and mitochondrial function on healthy male volunteers aged 18-65 years old.

CRiB2 is a study which aims to investigate whether cognitive remediation therapy is effective in improving the thinking skills and daily life functioning of people with bipolar disorder.

The COMP 006 study explores the delivery of an investigational medicine (COMP360) alongside psychological support for the treatment of depression which has not responded to antidepressant treatment.

ASCEnD is a clinical and cost-effectiveness study of aripiprazole combined with sertraline for patients with bipolar depression. It is running in 10 sites across the UK and recruitment is open now!

The RESTORE-LIFE study looking at the effectiveness and efficiency of Vagus Nerve Stimulation (VNS) in difficult to treat patients with depression.