Guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment resistant depression (BRIGhTMIND)

BRIGhTMIND is the name of a research study taking place in Nottingham Newcastle-upon-Tyne and London. The study is researching the effectiveness of two types of Transcranial Magnetic Stimulation treatments (TMS) designed to help people who are experiencing depression for which traditional treatments like medication and talking therapies or counselling haven’t worked. This type of depression is called treatment resistant depression

TMS is a new form of treatment for depression. A particular region of the brain is stimulated using a magnetic coil placed on the head. This stimulation activates cells in the brain which will go on to release a chemical. The imbalance of chemicals in the brains of depressed patients may be corrected. The effects of TMS will wear off over time.

International trials have shown it to be a safe procedure. It is widely used in America, Canada, Australia and some European countries. It has been recommended for use in the NHS in the UK by the National Institute for Health and Care Excellence (NICE) as a treatment for treatment resistant depression. For further guidance visit the NICE website.

BRIGhTMIND offers people the chance to try a new treatment for depression. It could be for you if you are:

  • 18 or over.
  • Treatment resistant depression for examples someone for whom at least 2 treatments you’ve tried haven’t worked, which means you have treatment resistant depression.
  • Happy to take part in treatment involving an MRI scan and 20 sessions of TMS.

If you are eligible and wish to take part in the study, no changes will be made to your current medication or treatment and this will not affect the standard of care you receive from your usual doctors and nurses.

For further information on the study you can visit the study website.

Or contact the BRIGhTMIND research Team on: BRIGhTMIND@cntw.nhs.uk