Trial of Psilocybin versus Escitalopram for Depression

Trial of psilocybin

Psilocybin is a naturally occurring chemical found in several species of mushrooms, sometimes referred to as ‘magic mushrooms’ and could have antidepressant properties, however research comparing psilocybin and established treatments for depression is lacking. This randomised controlled trial compared Psilocybin and Escitalopram with patients who have moderate to severe Major Depressive Disorder. No significant difference in antidepressant effects between Psilocybin and Escitalopram were found. Secondary outcomes favoured Psilocybin over Escitalopram. More research is needed to compare psilocybin with established antidepressants.

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Newcastle is taking part in a worldwide multi-centre study investigating the effects of psilocybin in treatment-resistant depression. To find out more about this study click here.