What is an atypical hallucinogen?

Psychedelics act on receptors including serotonin, dopamine (and mixed serotonin and dopamine receptors). They are described as acting on monoaminergic or glutamatergic mechanisms eg Psilocybin and LSD, Ketamine, Ecstasy/MDMA.

Atypical hallucinogens can affect multiple neurotransmitter systems. A group of unrelated distinct chemical substances with some hallucinogenic properties, exhibiting a diverse mechanism of action, legal status and therapeutic potentials.

The atypical hallucinogens are defined as substances capable of causing or giving rise to psychedelic-like effects through diverse pharmacological mechanisms in addition to the previously described monoaminergic and glutamatergic mechanisms. The atypical hallucinogens include the indole alkaloid Ibogaine, which affects multiple neurotransmitter systems, the kappa opioid receptor (KOR) agonist Salvinorin A, and the anticholinergics such as Atropine and Datura, also known as deliriants. Cannabis is sometimes attributed psychedelic-like properties and has exhibited therapeutic potential for several indications.