Lithium versus Quetiapine in Depression (LQD)

The LQD study is trying to work out which of two medications (lithium or quetiapine) added to an antidepressant is best in helping people with treatment resistant depression. The aim is to address the gap in the research literature on which of these medications is most effective over the course of a year. Future patients will benefit from the results of the study by knowing which (if any) treatment is more likely to improve their condition over a longer duration of time.

The study is being run from Northumberland, Tyne and Wear NHS Foundation Trust and Tees, Esk and Wear Valleys NHS Foundation Trust. Recruitment began in December 2016 and is currently ongoing.

Who can take part?

People can take part in the study if they:

  • Are aged 18 years or over
  • Are currently experiencing depression
  • Have tried two or more antidepressants in their current depressive episode which have not worked
  • Are currently taking an antidepressant
  • Do not have a diagnosis of bipolar disorder
  • Are not currently experiencing psychosis
  • Are not pregnant, currently breastfeeding, or a woman planning on getting pregnant in the near future
  • Have not used lithium or quetiapine during their current episode
  • Have a known contraindication to either quetiapine or lithium

If you are a patient and interested in taking part, please click here.

If you are a clinician and would like further information about this study, please click here.