The studies listed below are being conducted at Newcastle University, with links to NCMD. They are ongoing and from time to time need people to take part in them. Where this is the case, there is a link showing how you can get involved.
The Lithium versus Quetiapine in Depression (LQD) study is trying to work out which of two medications (lithium or quetiapine) added to an antidepressant is best in helping people with treatment resistant depression.Read more
The BLISS study looks at Bipolar disorder, a common and highly recurrent and debilitating psychiatric illness. Lithium effectively treats and prevents mania and depression, additionally reducing risk of suicide. We lack the ability to usefully predict response to lithium – clinical predictors require an established period of illness; relying on these delays potentially effective treatment....Read more
PAX-BD is a major trial examining a novel treatment for bipolar disorder, funded by the National Institute for Health Research’s (NIHR) Health Technology Assessment (HTA) Board. The study examines the effectiveness and safety of a drug, pramipexole which is currently used to treat Parkinson’s Disease, for patients with bipolar disorder who are depressed and have not responded to NICE recommended treatments.Read more
The safety and efficacy of psilocybin in participants with treatment-resistant depression (P-TRD).Read more
The purpose of RESTORE-LIFE is to collect information about subjects with difficult to treat depression (e.g., treatment resistant depression) who are referred for treatment with VNS Therapy. A review of past and current medical and psychiatric history and several questionnaires will be completed. These questionnaires will include questions about depression and how it affects quality of life and use of health care services. In addition participants might be asked to perform a test called “THINC-it” that evaluates changes in cognition.
This study is sponsored by LivaNova. The study is running across Europe and the UK. Centres involved in delivering the study are:
With 3 more UK site due to open by early 2019 (Bristol, Leicester and Somerset).